Search on: MUSCLE RELAXANTS, CENTRAL 
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Descriptor English:   Muscle Relaxants, Central 
Descriptor Spanish:   relajantes musculares centrales 
Descriptor Portuguese:   Relaxantes Musculares Centrais 
Synonyms English:   Central Muscle Relaxants
Centrally Acting Muscle Relaxants
Relaxants, Central Muscle  
Tree Number:   D27.505.696.510
D27.505.696.663.700.600
D27.505.954.427.525
Definition English:   A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) 
Indexing Annotation English:   refers to skeletal muscle relaxants only: smooth muscle relaxants = PARASYMPATHOLYTICS
See Related English:   Parasympatholytics
 
History Note English:   70; MUSCLE RELAXANTS was see under CURARE-LIKE AGENTS & MUSCLE RELAXANTS, CENTRAL & NEUROMUSCULAR DEPOLARIZING AGENTS 1970-74, was heading 1963-69 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   9315 
Unique Identifier:   D009125 

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